Bacterial Enzymes as Targets for Drug Discovery

Part I Primer of antibiotic discovery process 1. Antibacterial drug discovery: An introduction 2. Druggability of a target site 3. Dual inhibition as a novel strategy for antibiotic discovery 4. Conserved enzymes across the bacterial pathogens serves as great drug targets 5. Validation of drug targets using molecular methodologies 6. Selection of Enzymatic activity assays for validation of inhibitory potential 7. Computational tools to identify potential drug targets in bacteria 8. Antimicrobial drug resistance and bypassing strategies Part II Bacterial enzyme as drug targets 9. Strategic identification of novel enzymes as antibacterial drug targets 10. Inhibiting the replication by targeting topoisomerases 11. Aminoglycoside modifying Enzymes (AMEs) 12. Role of beta lactamases in antibiotic drug discovery 13. Combining efflux pump inhibitory agents for broad spectrum antibacterial activity 14. Ribosomal binding antibacterial agents 15. DNA dependent RNA polymerase as an attractive drug target 16. Polymyxins and their role as next generation inhibitory compounds 17. Arresting the peptidoglycan synthesis to kill the bacteria 18. Bacterial Proteases 19. Targeting lipase enzyme for drug discovery 20. Bacteriophage mechanisms for identification of target enzymes 21. Role of regulatory RNAs as antibacterial drug targets 22. Pathogen specific antibiotic discovery 23. Drug Repurposing: Tackling the antibiotic resistance with existing therapeutics