Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 8Human Diseases...

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M. A. Hayat (Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA)

Autophagy

Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 8Human Diseases...

M. A. Hayat (Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA)

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English

Academic Press Inc
14 January 2016

Hospital infections; Oncology; Immunology; Molecular biology

Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

Edited by: M. A. Hayat (Distinguished Professor Department of Biological Sciences Kean University Union NJ USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm, Spine: 25mm
Weight: 970g
ISBN: 9780128029374
ISBN 10: 0128029374
Pages: 418
Publication Date: 14 January 2016
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.