A Guide to Outcome Modeling In Radiotherapy and Oncology

Listening to the Data

Issam El Naqa (University of Michigan, Ann Arbor, USA)

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Hardback

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English

CRC Press Inc
02 March 2018

Radiotherapy; Probability & statistics; Medical physics

Series: Series in Medical Physics and Biomedical Engineering

This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches.

This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications.

Features:

Covers top-down approaches applying statistical, machine learning, and big data analytics and bottom-up approaches using first principles and multi-scale techniques, including numerical simulations based on Monte Carlo and automata techniques Provides an overview of the available software tools and resources for outcome model development and evaluation, and includes hands-on detailed examples throughout

Presents a diverse selection of the common applications of outcome modeling in a wide variety of areas: treatment planning in radiotherapy, chemotherapy and immunotherapy, utility-based and biomarker applications, particle therapy modeling, oncological surgery, and the design of adaptive and SMART clinical trials

Edited by: Issam El Naqa (University of Michigan Ann Arbor USA)
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 254mm, Width: 178mm,
Weight: 839g
ISBN: 9781498768054
ISBN 10: 1498768059
Series: Series in Medical Physics and Biomedical Engineering
Pages: 392
Publication Date: 02 March 2018
Audience: Professional and scholarly , College/higher education , Undergraduate , Primary
Format: Hardback
Publisher's Status: Active

Issam El Naqa is an Associate Professor of Radiation Oncology at the University of Michigan at Ann Arbor, USA.