50 Studies Every Neonatologist Should Know presents a selection of seminal trials in neonatology, including both cornerstones of practice and frontiers in trial design. The included trials cover a broad range of care topics in neonatology, as well as important learning points in a number of dimensions. The text explores each trial in a dedicated chapter, with a concise summary of methods and results, accompanied by a brief discussion of special considerations, including risks of bias, interpretation, and implications for practice. Additionally, there is a short interview with the trialist (or an editorial commentary) at the end of each chapter, to give a flavor of the ongoing conversation after trial publication.
As with all books in the ""50 Studies"" series, each study was selected using an objective selection criterion that included citations per year, high levels of evidence, clinical studies and trials, and a 3-stage Delphi review by international experts in the field. It is a must-read for neonatologists, trainees, or anyone involved in neonatal care or trial design.
Edited by:
MD John Zupancic ScD (Associate Professor of Pediatrics Associate Professor of Pediatrics Harvard Medical School),
MD Susanne Hay (Instructor in Pediatrics,
Instructor in Pediatrics,
Harvard Medical School),
MD Roger F. Soll (H. Wallace Professor of Neonatology,
H. Wallace Professor of Neonatology,
University of Vermont),
MD Barbara Schmidt,
MSc (Professor,
Department of Health Research Methods,
Evidence,
and Impact,
Professor,
Department of Health Research Methods,
Evidence,
and Impact,
McMaster University),
MD Haresh Kirpalani,
MSc (Professor Emeritus,
Department of Pediatrics,
Professor Emeritus,
Department of Pediatrics,
University Pennsylvania)
Imprint: Oxford University Press Inc
Country of Publication: United States
Dimensions:
Height: 241mm,
Width: 157mm,
Spine: 23mm
Weight: 544g
ISBN: 9780197646953
ISBN 10: 0197646956
Series: Fifty Studies Every Doctor Should Know
Pages: 368
Publication Date: 29 January 2025
Audience:
Professional and scholarly
,
Undergraduate
Format: Paperback
Publisher's Status: Active
Preface from the Series Editor Preface Contributors Intrapartum Care 1. A Controlled Trial of Antepartum Glucocorticoid Treatment for Prevention of the Respiratory Distress Syndrome in Premature Infants Sarah D. McDonald 2. Prevention of Early-Onset Neonatal Group B Streptococcal Disease with Selective Intrapartum Chemoprophylaxis Megan J. Turner and Clyde J. Wright 3. Reduction of Maternal-Infant Transmission of Human Immunodeficiency Virus Type 1 with Zidovudine Treatment Wes Onland and Anton H. van Kaam 4. A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy: The BEAM Trial Elizabeth Foglia Resuscitation 5. Resuscitation of Asphyxiated Newborn Infants with Room Air or Oxygen: The Resair 2 Trial Elizabeth Baker and Peter G. Davis 6. Delivery Room Management Of The Apparently Vigorous Meconium-Stained Neonate Charles Christoph Roehr 7. Randomized Trial of Occlusive Wrap for Heat Loss Prevention in Preterm Infants: The HeLP Trial Anup Katheria 8. Association of Umbilical Cord Milking Versus Delayed Umbilical Cord Clamping with Death or Severe Intraventricular Hemorrhage among Preterm Infants: The PREMOD2 Trial Seh Hyun Kim and Han-Suk Kim 9. Effect of Sustained Inflations Versus Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death among Extremely Preterm Infants: The SAIL Trial Susanne Hay and John Zupancic Cardiovascular 10. Effects of Indomethacin in Premature Infants with Patent Ductus Arteriosus Souvik Mitra 11. Extracorporeal Circulation in Neonatal Respiratory Failure Elizabeth Baker and Peter G. Davis 12. UK Collaborative Randomised Trial of Neonatal Extracorporeal Membrane Oxygenation Brianna Liberio and Clyde J. Wright 13. Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure: The NINOS Trial Dirk Bassler Respiratory 14. Prevention of Neonatal Respiratory Distress Syndrome by Tracheal Instillation of Surfactant Colm P.F. O'Donnell 15. Collaborative Quality Improvement to Promote Evidence Based Surfactant for Preterm Infants: A Cluster Randomised Trial Ashraf Kharrat and Prakesh S. Shah 16. Pressure-Regulated Volume Control Ventilation Versus Synchronized Intermittent Mandatory Ventilation for Very Low-Birth-Weight Infants Erik A. Jensen 17. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity: The CAP Trial Dirk Bassler 18. Outcome at Two Years of Age of Infants from The DART Study: A Multicenter, International, Randomised, Controlled Trial of Low-Dose Dexamethasone Anton H. van Kaam and Wes Onland 19. Early CPAP Versus Surfactant in Extremely Preterm Infants: The SUPPORT Trial Brett J. Manley 20. Target Ranges of Oxygen Saturation in Extremely Preterm Infants: The SUPPORT Trial James I. Hagadorn 21. A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Brett J. Manley 22. High-Flow Nasal Cannulae in Very Preterm Infants after Extubation: The HIPERSPACE Trial Charles Christoph Roehr Nutrition 23. Randomised Trial of Early Diet in Preterm Babies and Later Intelligence Quotient Michelle Fernandes and Jon Dorling 24. Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants Susanne Hay and Axel R. Franz 25. Promotion of Breastfeeding Intervention Trial: The PROBIT Trial Nicholas D. Embleton 26. Dextrose Gel for Neonatal Hypoglycemia: The Sugar Babies Trial Adel Mohamed, Jyotsna Shah, and Prakesh S. Shah 27. Effect of Supplemental Donor Human Milk Compared with Preterm Formula on Neurodevelopment of Very Low-Birth-Weight Infants at 18 Months: The DOMINO Trial Nicholas D. Embleton Thermal 28. The Influence of the Thermal Environment upon the Survival of Newly Born Premature Infants David Osborn 29. Kangaroo Mother Versus Traditional Care for Newborn Infants. Srinivas Murki Infectious Disease / Immunology 30. Palivizumab, A Humanized Respiratory Syncytial Virus Monoclonal Antibody, Reduces Hospitalization from Respiratory Syncytial Virus Infection in High-Risk Infants: The IMpact-RSV Trial Brian C. King 31. Probiotic Effects on Late-Onset Sepsis in Very Preterm Infants: The ProPrems Trial Deena Thomas and M. Jeeva Shankar 32. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease Li Ma Hematology 33. Hemorrhagic Disease of the Newborn Anna E. Curley 34. Effects of Early Erythropoietin Therapy on the Transfusion Requirements of Preterm Infants Below 1250 Grams Birth Weight Anna E. Curley 35. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants: The TOP Trial Axel R. Franz 36. A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants: The PENUT Trial Nicholas D. Embleton 37. Randomized Trial of Platelet-Transfusion Thresholds in Neonates: The PlaNeT Trial Ravi Mangal Patel Ophthalmology 38. Multicenter Trial of Cryotherapy for Retinopathy of Prematurity, Preliminary Results: The CRYO-ROP Trial James I. Hagadorn 39. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity, Primary Outcomes: The STOP-ROP Trial Souvik Mitra 40. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity: The BEAT-ROP Trial Brian C. King Neurology 41. Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight Infants: The TIPP Trial Peter W. Fowlie and William McGuire 42. Effects of Morphine Analgesia in Ventilated Preterm Neonates, Primary Outcomes: The NEOPAIN Trial Souvik Mitra 43. Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic Encephalopathy Anton H. van Kaam and Wes Onland 44. Effectiveness of Sucrose Analgesia in Newborns Undergoing Painful Medical Procedures David Osborn 45. A Randomized Trial of Prenatal Versus Postnatal Repair of Myelomeningocele: The MOMS Trial Sara DeMauro 46. Neurodevelopmental Outcome at Five Years of Age after General Anaesthesia or Awake-Regional Anaesthesia In Infancy: The GAS Trial Sara B. DeMauro 47. Levetiracetam Versus Phenobarbital for Neonatal Seizures: The NEOLEV2 Trial Stefan Johansson 48. Hypothermia for Moderate or Severe Neonatal Encephalopathy in Low-Income and Middle-Income Countries: The HELIX Trial Srinivas Murki Health Services 49. Newborn-Care Training and Perinatal Mortality in Developing Countries: The First Breath Trial Danielle E.Y. Ehret 50. Effectiveness of Family Integrated Care in Neonatal Intensive Care Units on Infant and Parent Outcomes Evangelia Myttaraki and Chris Gale
Susanne Hay, MD is an academic neonatologist with an interest in evidence-based care. She graduated from Harvard College and earned a medical degree from Columbia College of Physicians & Surgeons. She went on to train in pediatrics in the Boston Combined Residency Program, and then completed the Harvard Combined Fellowship in Neonatology. Dr. Hay is now an attending neonatologist at the Beth Israel Deaconess Medical Center and an instructor in pediatrics at the Harvard Medical School. Her primary research focus is data synthesis, evaluating the neonatal research landscape and how we know what we know, as well as how we might address inefficiencies. Roger F. Soll, MD is the H. Wallace Professor of Neonatology at the University of Vermont, Vice President of the Vermont Oxford Network (VON) and Director of the VON Institute for Evidence Based Practice. He is the author of numerous peer reviewed articles and book chapters on the subject of surfactant replacement therapy and evidence-based medicine. Dr. Soll graduated from Cornell University in 1975 and received his M.D. degree from the University of Health Sciences/Chicago Medical School in 1978. He completed his residency training in Pediatrics at Bellevue Hospital/New York University Medical Center in 1981. After 2 years with the Public Health Service, Dr. Soll returned to academic training. He completed the fellowship in Neonatal Perinatal Medicine at the University of Vermont in 1985 and has remained in Vermont ever since. Barbara Schmidt, MD, MSc is a neonatologist and clinical epidemiologist who led three large international neonatal randomized trials with clinically important, long-term outcomes: (1) Trial of Indomethacin Prophylaxis in Preterms (TIPP); (2) Caffeine for Apnea of Prematurity (CAP) Trial; and (3) Canadian Oxygen Trial (COT). Dr. Schmidt has received the highest honors in her specialty, including the Douglas K Richardson Award from the Society for Pediatric Research, the Virginia Apgar Award from the American Academy of Pediatrics, and the Arvo Ylppo¨ Medal from the Finnish Pediatric Research Foundation. She is a member of the Order of Canada. Haresh Kirpalani, MD, MSc is a neonatologist and clinical epidemiologist. He led three large randomized trials with clinically important outcomes: (1) Nasal Intermittent Positive-Pressure Ventilation (NIPPV) (2) Transfusion of Prematures (TOP); and (3) Sustained Aeration of Infant Lungs (SAIL). He has received several prizes for teaching and mentorship, for clinical neonatology and principles of evidence based practice. He was a founding member of
