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English
Academic Press Inc
19 February 2020
Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.
Edited by:  
Imprint:   Academic Press Inc
Country of Publication:   United States
Dimensions:   Height: 235mm,  Width: 191mm, 
Weight:   810g
ISBN:   9780128191323
ISBN 10:   0128191325
Pages:   450
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

Angel L. Pey obtained his Bachelor degree in Chemistry in 1999 at the Universidad Complutense in Madrid and his Ph.D. in Molecular Biology at the Universidad Autónoma in Madrid in 2004. His Ph.D. focused on genotype-phenotype correlations in Phenylketonuria and the molecular basis of tetrahydrobiopterin-responsive patients with this disease. In 2004, he moved as a post-doc to the lab directed by Prof. Aurora Martinez at the Department of Biomedicine of the University of Bergen (Norway) to work with novel structure-based and biophysical studies on phenylketonuria and therapeutic approaches for this disease based on pharmacological chaperones. In 2009, he moved to the Department of Physical Chemistry, University of Granada, to work as a Ramón y Cajal Fellow. He established his own line of research combining approaches from different disciplines (molecular and cellular biology, structural and computational biology, biochemistry and biophysics) to get an integrative view into the molecular basis and genotype-phenotype correlations in several rare and common hereditary diseases. In 2019, he was appointed as Associated Professor in Physical Chemistry. Over the years, he has taught in different programs on Enzymology, Advanced biophysical techniques, General and Physical Chemistry, and mentored several Ph.D., Master and undergraduate students. He is author of over 70 peer-reviewed scientific papers and book chapters.

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