Animal Models in Toxicology

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Shayne C. Gad Shayne C. Gad (Gad Consulting Services, Raleigh, North Carolina, USA)

Animal Models in Toxicology

Shayne C. Gad, Shayne C. Gad (Gad Consulting Services, Raleigh, North Carolina, USA)

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English

CRC Press Inc
17 July 2015

Toxicology (non-medical); Animal physiology; Animal pathology & diseases

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory ""course"" along with guidance to the literature for a more detailed understanding.

This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

Edited by: Shayne C. Gad, Shayne C. Gad (Gad Consulting Services, Raleigh, North Carolina, USA)
Imprint: CRC Press Inc
Country of Publication: United States
Edition: 3rd edition
Dimensions: Height: 254mm, Width: 178mm,
Weight: 2.320kg
ISBN: 9781466554283
ISBN 10: 1466554282
Pages: 1168
Publication Date: 17 July 2015
Audience: General/trade , College/higher education , ELT Advanced , Primary
Format: Hardback
Publisher's Status: Active

Introduction. The Mouse. The Rat. The Hamster. The Guinea Pig. Rabbit. The Ferret. The Dog. Primates. The Minipig. Alternative Species. Clinical Pathology of Laboratory Animals. Telemetry in Nonclinical Drug Safety Assessment Studies. Molecular Imaging Techniques in Laboratory Animals. Genetically Modified Animal Models. Model Selection and Scaling (Allometry). Susceptibility Factors. Laws, Regulations, and Guidelines for Animal Care and Use in Research. Necropsy and Gross Pathology. Immunology Laboratory Endpoints for Assessment of Immunomodulators in Preclinical Studies and Case Studies Using Anti-CD3 mAb in Cynomolgus Monkey

Edited by Shayne Cox Gad, PhD, DABT, is the principal of Gad Consulting Services in Raleigh, North Carolina. He has more than 38 years of broad-based experience in toxicology, drug, device development, document preparation, statistics, and risk assessment, having previously been the director of toxicology and pharmacology for Synergen, director of medical affairs technical support system services for Becton Dickinson, and senior director of product safety and pharmacokinetics for G.D. Searle. He is past president of the American College of Toxicology and Roundtable of Toxicology Consultants and a board-certified toxicologist. Dr. Gad has published 47 books and more than 350 chapters, papers, and abstracts.

Reviews for Animal Models in Toxicology

""…should be in every toxicology laboratory that performs research involving animals. No other book … provides the same breadth and depth of information as found here…"" —Michele T. Pritchard, PhD, University of Kansas Medical Center in Doody’s Book Reviews